Culture is a complex concept. In medicine, managing cultural differences is essential to providing high-quality health care. For travel healthcare professionals this is even more crucial as a traveler will work 13 weeks at a time at each assignment. A travel healthcare worker can be exposed to many new cultures and facilities a year. Learning how to be a great “new person” at a healthcare facility and how to handle different systems, pieces of equipment, management, co-workers, and communication styles is key to thriving in a travel healthcare role.